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Amyloidoza
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Improvement in survival in AL amyloidosis throughout 30 years  »  PDF - 281 kB
Careful physical exam seeking other potential organ involvement e.g. proteinuria, periorbital purpura  »  PDF - 58 kB
Bortezomib and dexamethasone consolidation following riskadapted melphalan and stem cell transplantation for patients with newly diagnosed light chain amyloidosis  »
H Landau, H Hassoun, MA Rosenzweig, M Maurer, J Liu, C Flombaum, C Bello, E Hoover, E Riedel, S Giralt and RL Comenzo - © 2012 Macmillan Publishers Limited.		  PDF - 1,10 MB
Transthyretin (TTR) Cardiac Amyloidosis  »
Frederick L. Ruberg and John L. Berk - © Circulation. 2012 American Heart Association, Inc.		  PDF - 3,53 MB
How I diagnose amyloidosis  »
Nelson Leung, Samih H. Nasr and Sanjeev Sethi - © 2012 by The American Society of Hematology. Blood		  PDF - 597 kB
Activity of pomalidomide in patients with immunoglobulin light-chain amyloidosis  »
Angela Dispenzieri, Francis Buadi, Kristina Laumann, Betsy LaPlant, Suzanne R. Hayman, Shaji K. Kumar, David Dingli, Steven R. Zeldenrust, Joseph R. Mikhael, Robert Hall, S. Vincent Rajkumar, Craig Reeder, Rafael Fonseca, P. Lief Bergsagel, A. Keith Stewart, Vivek Roy, Thomas E. Witzig, John A. Lust, Stephen J. Russell, Morie A. Gertz and Martha Q. Lacy - © 2012 by The American Society of Hematology. Blood		  PDF - 317 kB
Lenalidomide, cyclophosphamide, and dexamethasone (CRd) for light-chain amyloidosis: long-term results from a phase 2 trial  »
Shaji K. Kumar, Suzanne R. Hayman, Francis K. Buadi, Vivek Roy, Martha Q. Lacy, Morie A. Gertz, Jacob Allred, Kristina M. Laumann, Leif P. Bergsagel, David Dingli, Joseph R. Mikhael, Craig B. Reeder, A. Keith Stewart, Steven R. Zeldenrust, Philip R. Greipp, John A. Lust, Rafael Fonseca, Stephen J. Russell, S. Vincent Rajkumar and Angela Dispenzieri - © 2012 by The American Society of Hematology. Blood		  PDF - 297 kB
A phase 1/2 study of lenalidomide with low-dose oral cyclophosphamide and low-dose dexamethasone (RdC) in AL amyloidosis  »
Efstathios Kastritis, Evangelos Terpos, Maria Roussou, Maria Gavriatopoulou, Constantinos Pamboukas, loannis Boletis, Smaragda Marinaki, Theofanis Apostolou, Nikitas Nikitas, Georgios Gkortzolidis, Eurydiki Michalis, Sossana Delimpasi and Meletios A. Dimopoulos - © 2012 by The American Society of Hematology. Blood		  PDF - 276 kB
Activity of pomalidomide in patients with immunoglobulin light-chain amyloidosis  »
Angela Dispenzieri, Francis Buadi, Kristina Laumann, Betsy LaPlant, Suzanne R. Hayman, Shaji K. Kumar, David Dingli, Steven R. Zeldenrust, Joseph R. Mikhael, Robert Hall, S. Vincent Rajkumar, Craig Reeder, Rafael Fonseca, P. Lief Bergsagel, A. Keith Stewart, Vivek Roy, Thomas E. Witzig, John A. Lust, Stephen J. Russell, Morie A. Gertz and Martha Q. Lacy - © 2012 by The American Society of Hematology. Blood		  PDF - 317 kB
Lenalidomide, cyclophosphamide, and dexamethasone (CRd) for light-chain amyloidosis: long-term results from a phase 2 trial  »
Shaji K. Kumar, Suzanne R. Hayman, Francis K. Buadi, Vivek Roy, Martha Q. Lacy, Morie A. Gertz, Jacob Allred, Kristina M. Laumann, Leif P. Bergsagel, David Dingli, Joseph R. Mikhael, Craig B. Reeder, A. Keith Stewart, Steven R. Zeldenrust, Philip R. Greipp, John A. Lust, Rafael Fonseca, Stephen J. Russell, S. Vincent Rajkumar and Angela Dispenzieri - © 2012 by The American Society of Hematology. Blood		  PDF - 297 kB
CyBorD: stellar response rates in AL amyloidosis  »
Giampaolo Merlini - © 2012 by The American Society of Hematology. Blood		  PDF - 336 kB
Cyclophosphamide-bortezomib-dexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis  »
Joseph R. Mikhael, Steven R. Schuster, Victor H. Jimenez-Zepeda, Nancy Bello, Jacy Spong, Craig B. Reeder, A. Keith Stewart, P. Leif Bergsagel and Rafael Fonseca - © 2012 by The American Society of Hematology. Blood		  PDF - 229 kB
Cyclophosphamide, bortezomib, and dexamethasone therapy in AL amyloidosis is associated with high clonal response rates and prolonged progression-free survival  »
Christopher P. Venner, Thirusha Lane, Darren Foard, Lisa Rannigan, Simon D. J. Gibbs, Jennifer H. Pinney, Carol J. Whelan, Helen J. Lachmann, Julian D. Gillmore, Philip N. Hawkins and Ashutosh D. Wechalekar - © 2012 by The American Society of Hematology. Blood		  PDF - 215 kB
Light chain deposition disease: novel biological insights and treatment advances  »
V. H. Jimenez-Zepeda - © International Journal of Laboratory Hematology. 2012 Blackwell Publishing Ltd.		  PDF - 192 kB
How to manage primary amyloidosis  »
MA Gertz - © 2012 Macmillan Publishers Limited		  PDF - 388 kB
Reliable typing of systemic amyloidoses through proteomic analysis of subcutaneous adipose tissue  »
Francesca Brambilla, Francesca Lavatelli, Dario Di Silvestre, Veronica Valentini, Rossana Rossi, Giovanni Palladini, Laura Obici, Laura Verga, Pierluigi Mauri and Giampaolo Merlini - © Blood. 2012 by The American Society of Hematology		  PDF - 395 kB
Revised Prognostic Staging System for Light Chain Amyloidosis Incorporating Cardiac Biomarkers and Serum Free Light Chain Measurements  »
Shaji Kumar, Angela Dispenzieri, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, Colin Colby, Kristina Laumann, Steve R. Zeldenrust, Nelson Leung, David Dingli, Philip R. Greipp, John A. Lust, Stephen J Russell, Robert A. Kyle, S. Vincent Rajkumar, Marie A. Gertz - © Journal Of Clinical Oncology. 2012 by American Society of Clinical Oncology		  PDF - 611 kB
Amyloid diseases of the heart: current and future therapies  »
S. W. Dubrey and R.L. Comenzo - © Review. The Author 2012. Published by Oxford University Press on behalf of the Association of Physicians		  PDF - 366 kB
After several months of nephrology and respiratory investigation, Malvyn Benjamin was eventually diagnosed with amyloidosis. Here he describes his experience of the condition and its treatment  »
Malvyn Benjamin petient, Simon Gibbs haematology research teltow - © Practice. BMJ Publishing Group Ltd 2011 		 PDF - 152 kB
Outcome of AL amyloidosis after high-dose melphalan and autologous stem cell transplantation: long-term results in a series of 421 patients  »
Maria Teresa Cibeira, Vaishali Sanchorawala, David C. Seldin, Karen Quillen, John L. Berk, Laura M. Dember, Adam Segal, Frederick Ruberg, Hans Meier-Ewert, Nancy T. Andrea, J. Mark Sloan, Kathleen T. Finn, Gheorghe Doros, Joan Blade and Martha Skinner - © Blood. 2011 by The American Society of Hematology		  PDF - 327 kB
Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis  »
Jennifer Ellis Ward, Ruiyi Ren, Gianluca Toraldo, Pam SooHoo, Jian Guan, Carl O'Hara, Ravi Jasuja, Vickery Trinkaus-Randall, Ronglih Liao, Lawreen H. Connors and David C. Seldin - © Blood. 2011 by The American Society of Hematology		  PDF - 462 kB
Efficacy and safety of once-weekly and twice-weekly bortezomib in patients with relapsed systemic AL amyloidosis: results of a phase 1/2 study  »
Donna E. Heece, Ute Heqenbart, Vaishali Sanchorawala, Giampaolo Merllni, Giovanni Palladlni, Joan Blade, Jean-Paul Ferrnand, Hani Hassoun,Leonard Heffner, Robert A. Vescio, Kevin Liu, Christopher Enny, Dixie-Lee Esseltine, Helgi van de Velde, Andrew Cakana and Raymond L. Comenzo - © Blood. 2011 by The American Society of Hematology		  PDF - 214 kB
Bortezomib in a phase 1 trial for patients with relapsed At amyloidosis: cardiac responses and overall effects  »
S.W. Dubrey, D.E. Reece, V. Sanchorawala, U. Hegenbart, G. Merlini, G. Palladini, J.P. Fermand, R.A. Vescio, J. Blades, L.T. Heffner, H. Hassoun, X. L1u, C. Enny, P. Ramaswami, Y. Elsayed, H. Van De Velde, S. Mortimer, A. Cakana and R.L. Comenzo for the Velcade Can2007 Study Group - © The Author 2011. Published by Oxford University Press on behalf of the Association of Physicians		  PDF - 166 kB
Amyloidosis: Pathogenesis and New Therapeutic Options  »
Giampaolo Merlini, David C. Seldin and Morie A. Gertz - © 2011 American Society of Clinical Oncology		  PDF - 927 kB
Discordance between serum cardiac biomarker and immunoglobulin-free light-chain response in patients with immunoglobulin light-chain amyloidosis treated with immune modulatory drugs  »
Angela Dispenzieri, David Din~li, Shaji K. Kumar, S. Vincent Rajkumar, Martha Q. Lacy, Suzanne Hayman, Frances Buadi, Stephen Zeldenrust, Nelson l.eung, Kristen Detweiler-Short, John A. Lust, Stephen J. Russell, Robert A. Kyle and Morie A. Gertz - © American Journal of Hematology 2010		  PDF - 163 kB
Serum immunoglobulin free light chain measurement in AL amyloidosis: prognostic value and correlations with clinical features  »
Shaji Kumar, M.D., Angela Dispenzieri, M.D., Jerry A. Katzmann, M.D., Dirk R. Larson, Colin L. Colby, Martha Q. Lacy, M.D., Suzanne R. Hayman, M.D., Francis K. Buadi, M.D., Nelson Leung, M.D., Steve R. Zeldenrust, M.D.,Ph.D., Marina Ramirez-Alvarado, Ph.D., Raynell J. Clark, Robert A. Kyle, M.D., S. Vincent Rajkumar, M.D., Morie A. Gertz. M.D. - Blood First Edition Paper, prepublished online August 26, 2010		  PDF - 333 KB
Bortezomib After ASCT 2010  »
Haematologica | 2010; 95(3)		  PDF - 950 KB
Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients  »
Francesca Gay, Suzanne R. Hayman, Martha Q. Lacy, Francis Buadi, Morie A. Gertz, Shaji Kumar, Angela Dispenzieri, Joseph R. Mikhael, P. Leif Bergsagel, David Dingli, Craig B. Reeder, John A. Lust, Stephen J. Russell, Vivek Roy, Steven R. Zeldenrust, Thomas E. Witzig, Rafael Fonseca, Robert A. Kyle, Philip R. Greipp, A. Keith Stewart, andS. Vincent Rajkumar - BLOOD, 18 February 2010 - Volume 115, Number 7		  PDF - 189 KB
How I treat amyloidosis  »
Raymond L. Comenzo		  PDF - 1,88 MB
Mechanism of action of lenalidomide in hematological malignancies  »
Venumadhav Kotla†, Swati Goel†, Sangeeta Nischal, Christoph Heuck, Kumar Vivek, Bhaskar Das and Amit Verma - Journal of Hematology & Oncology 2009, 2:36		  PDF - 948 KB
Histological regression of amyloid in AL amyloidosis is exclusively seen after normalization of serum free light chain  »
Ingrid I. van Gameren, Martin H. van Rijswijk, Johan Bijzet, Edo Vellenga, and Bouke P. Hazenberg		  PDF - 219 KB
Weekly and twice-weekly bortezomib in patients with systemicAL amyloidosis: results of a phase 1 dose-escalation study  »
Donna E. Reece, Vaishali Sanchorawala, Ute Hegenbart, Giampaolo Merlini, Giovanni Palladini, Jean-Paul Fermand, Robert A. Vescio, Xiangyang Liu, Yusri A. Elsayed, Andrew Cakana and Raymond L. Comenzo, for the VELCADECAN2007 Study Group - BLOOD, 20 AUGUST 2009 - VOLUME 114, NUMBER 8		  PDF - 259 KB
Current treatment of AL amyloidosis  »
Giovanni Palladini and Giampaolo Merlini		  PDF - 280 KB
Modern Treatment of Amyloidosis: Unresolved Questions  »
Laura M. Dember - Journal of the American Society of Nephrology J Am Soc Nephrol 20: 469–472, 2009		  PDF - 63 KB
Biopsy of subcutaneus fatty tissue for diagnosis of systemic amyloidosis  »
Bogov B, Lubomirova M, Kiperova B - HIPPOKRATIA 2008, 12, 4		  PDF - 526 KB
Effieaey of bortezomib in systemie AL amyloidosis with relapsedjrefraetory elonal disease  »
Ashutosh O. Wechalekar, Helen J. Lachmann, Mark Offer, Philip N. Hawkins, and Julian O. Gillmore		  PDF - 253 KB
Treatment ot light chain (AL) amyloidosis with the combination ot bortezomib and dexamethasone  »
Efstathios Kastritis, Athanasios Anagnostopoulos, Maria Roussou, Savvas Toumanidis, Constantinos Pamboukas, Magdalini Migkou, Anna Tassidou, Irini Xilouri, Sossana Delibasi, Erasmia Psimenou, Sofia Mellou, Evangelos Terpos, John Nanas, Meletios A. Dimopoulos		  PDF - 518 KB
Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis  »
Harun Akar, David C. Seldin, Barbarajean Magnani, Carl O’hara, John L. Berk1, Christopher Schoonmaker, Howard Cabral, Laura M. Dember, Vaishali Sanchorawala, Lawreen H. Connors, Rodney H. Falk & Martha Skinner		  PDF - 66 KB
Waldenström Macroglobulinemia  »
Irene M. Ghobrial MD, Thomas E. Witzig MD		  PDF - 427 KB
Definition of Organ Involvement and Treatment Response in Immunoglobulin Light Chain Amyloidosis (AL): A Consensus Opinion From the 10th International Symposium on Amyloid and Amyloidosis  »
Morie A. Gertz, Ray Comenzo, Rodney H. Falk, Jean Paul Fermand, Bouke P. Hazenberg, Philip N. Hawkins, Giampaolo Merlini, Philippe Moreau, Pierre Ronco, Vaishali Sanchorawala, Orhan Sezer, Alan Solomon and Giles Grateau - American Journal of Hematology 79:319–328 (2005)		  PDF - 119 KB
Bortezomib in the treatment of AL amyloidosis: targeted therapy?  »
Roberto Sitia, Giovanni Palladini, Giampaolo Merlini - haematologica/the hematology journal | 2007; 92(10)		  PDF - 257 KB
An intriguing case of primary amyloidosis with cardiac involvement: Symptomatic and echocardiographic improvement with thalidomide treatment  »
Il-Young Oh, Hyung-Kwan Kim, Dae-Won Sohn, Young-Bae Park - International Journal of Cardiology xx (2005) xxx - xxx		  PDF - 546 KB
Amyloidosis  »
Raymond L. Comenzo, MD		  PDF - 878 KB
Current and Emerging Views and Treatments of Systemic Immunoglobulin Light-Chain (AL) Amyloidosis  »
Raymond L. Comenzo Cytotherapy Laboratory, Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA - Herrera GA (ed): The Kidney in Plasma Cell Dyscrasias. Contrib Nephrol. Basel, Karger, 2007, vol 153, pp 195–210		  PDF - 103 KB



Opracował: Dr hab. med. Artur Jurczyszyn
Klinika Hematologii Szpital Uniwersytecki w Krakowie
31-501 Kraków, ul. Kopernika 17
tel.  +48 12 424 7426  lub  +48 12 424 7633



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